I am currently an Professor of Pediatrics at Columbia University and the Pediatric Endocrine Fellowship Director at Columbia University Medical Center- Children's Hospital. I have trained as Pediatric Endocrinologist with a record of achievement in both the clinical and the laboratory arenas. In addition to my clinical training, I finished a Master of Science Training Program in Clinical Research, a NIH-funded program offered by the Department of Epidemiology and Biostatistics at Albert Einstein College of Medicine. This program provided me with a solid foundation in epidemiology, statistics, data analysis, hypothesis development, and study design. During my fellowship and early faculty career I have developed a special interest in fetal development as well as fetal programming of adult diseases, such as obesity, insulin resistance, hyperandrogenemia and diabetes.
I have spent a significant part of my time doing basic science research that asks relevant questions in the area of fetal programming of adult disease, and how that relates to my patient population. I had actively collaborated with Dr. Rebecca Simmons, a well known expert in adult complications of altered fetal growth, who has developed a hypoxic rodent model of intrauterine growth restriction, Dr Charron, a well known expert on the epigenetic basis of disease. Dr. Charron and I were poised to make novel contributions to our understanding of the molecular mechanisms that program susceptibility to obesity and metabolic disease due to an adverse maternal metabolic milieu such as obesity and/or insulin resistance.
Currently as the Pediatric Endocrine Fellowship Director my job is to guide and mentor the fellows (one fellow a year for 3 years) in their research projects, I am in charge of the fellows’ education, including organizing and implementing the board reviews course and the continuity clinic infrastructure. I am the current mentor of our second year fellow Dr. Klein. Dr. Klein recently submitted a research application for an Endocrine Fellows Foundation Research Grant to support his pilot study entitled: “Risk Gradient and Correlation of Minimally and Non-invasive Measures of Cardiometabolic Health in Pediatric Metabolically Healthy Obese and Metabolically Unhealthy Obese Subjects”. The foundation of Jason’s study is to differentiate metabolically healthy from unhealthy overweight/obese adolescents by using a comprehensive anthropometric, laboratory and vascular assessment. Since the risks associated with obesity are not consistent among populations, it is crucial to understand the differences between metabolically healthy and unhealthy obese children in order to achieve appropriate intervention and prevention for our patients.
I have published my research in more than 50 peer reviewed articles in journals such as The Journal of Clinical Investigations, The Journal of Biological Chemistry, Diabetes, Endocrinology and American Journal of Physiology, to name a few. Similarly, I have presented my research findings as well as another endocrine topics at both national and International Meetings.
Over the years, I have developed a special interest in the diagnosis and treatment of thyroid disease in pediatrics. I am the Co-Director of the Pediatric Thyroid Center at Morgan Stanley Children's Hospital, Columbia University, NY, NY
I am an active member of the Pediatric Endocrine Society (PES), member to the pediatric endocrinology subcommittee at the American Board of Pediatrics (ABP) (2021- 2027) and member to the ACGME Review Committee for Pediatrics (2021- 2027).
As a physician-scientist, my scientific as well medical contributions, will have a substantial effect on the lives of patients with endocrine disorders. Given my research focus and my comprehensive expertise and management of neonatal as well as pediatric condition such as insulin resistance, obesity, hyperandrogenemia and type 2 diabetes mellitus, PCOS, and thyroid disease, together I will provide a unique prospective and ability to diagnose and treat this conditions.